MG-277

Overview

MG-277, a molecular glue degrader, effectively induces degradation of a translation termination factor based on Cereblon E3 ligand, GSPT1 , with a DC 50 of 1.3 nM. MG-277 potently inhibits tumor cell growth in a p53-independent manner, with IC 50 s of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells, respectively. Anticancer activity.

Application

Products | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-130122
• CAS No.: 2411085-89-5
• Molecular Formula: C41H42Cl2FN5O5
• Molecular Weight: 774.71
• Purity: 98.68%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: 5 mg/mL (6.45 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source