CL-385319

Overview

CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection . CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > Endogenous Metabolite

Product Information

• Catalog No.: HY-130178
• CAS No.: 1210501-46-4
• Molecular Formula: C15H19ClF4N2O
• Molecular Weight: 354.77
• Purity: 99.91%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 2.5 mg/mL (7.05 mM); Clear solution
• Availability: In-stock

Source

Original product source