Emamectin B1a

Overview

Emamectin B1a (L-656,748) is a semisynthetic derivative of avermectin B1a that binds to GABA receptors (Ki=17.6 nM in rat brain membranes) and enhances GABA responses. Emamectin B1a acitivates GABAA receptors α1β1γ2 , α1β2γ2 , and α1β3γ2 with IC 50 s of 57, 210, and 49.8 nM, respectively. Emamectin B1a also binds to glycine receptors , inhibiting glycine receptors with an IC 50 =218 nM in rat spinal cord. Emamectin B1a (1.067 ng/mL) caused 90% mortality of S. exigua larvae in foliar spray bioassays and topical application, making it more toxic than avermectin B1.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Infection | Products > Signaling Pathways > GABA Receptor

Product Information

• Catalog No.: HY-130349
• CAS No.: 121124-29-6
• Molecular Formula: C49H75NO13
• Molecular Weight: 886.12
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source