Propargyl-PEG4-acid

Overview

Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib ( HY-10997 )-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC 50 of 200 nM in THP-1 cells. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTAC Linkers

Product Information

• Catalog No.: HY-130481
• CAS No.: 1415800-32-6
• Molecular Formula: C12H20O6
• Molecular Weight: 260.28
• Purity: 97.0%
• Storage: Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source