RO-0335 is a novel and potent diphenylether nonnucleoside reverse transcriptase inhibitor (NNRTI) . RO-0335 inhibits Wt HIV-1 with an IC 50 of 1.1 nM and retained activity (IC 50 < 100 nM) against 92% of a large number of NNRTI-resistant clinical isolates.
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