Boc-C1-PEG3-C4-OBn ( PROTAC Linker 15) is a PROTAC linker , which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs , such as PROTAC SGK3 degrader-1 ( HY-125878 ). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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