N6-(2-Aminoethyl)-NAD+ (6-AE-NAD+) is an adenine-modified NAD analog with coenzyme activity and the property of targeting lactate dehydrogenase ( LDH ). N6-(2-Aminoethyl)-NAD+ undergoes transient affinity binding with LDH , thereby crosslinking the enzyme monolayer into an integrated electrode. N6-(2-Aminoethyl)-NAD + is a component of the PQQ ( HY-100196 )-NAD + binary interface, and supports the bioelectrocatalytic oxidation of lactate through PQQ-mediated immobilized NADH oxidation.
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