CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV) , with excellent cellular antiviral activity ( EC 90 =270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH) , which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools.
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