Nepicastat (SYN117) is a selective, potent, and orally active inhibitor of dopamine-beta-hydroxylase . Nepicastat (SYN117) produces concentration-dependent inhibition of bovine ( IC 50 =8.5 nM) and human ( IC 50 =9 nM) dopamine-beta-hydroxylase. Nepicastat (SYN117) can cross the blood-brain barrier (BBB).
Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Dopamine β-hydroxylase
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