Finafloxacin is an orally active fourth-generation fluoroquinolone broad-spectrum antibiotic . Finafloxacin exhibits stronger antibacterial activity in acidic pH environments and is not easily affected by bacterial multidrug efflux transporters. Finafloxacin is effective against a variety of extracellular pathogenic bacteria, and can also accumulate in macrophages, showing excellent antibacterial activity against intracellular Staphylococcus aureus , Listeria monocytogenes , Legionella pneumophila , Burkholderia pseudomallei , and other pathogens. Finafloxacin has been approved by the U.S. FDA for research on acute otitis externa mediated by Pseudomonas aeruginosa . Finafloxacin is also used in studies related to diseases such as melioidosis, inhalational tularemia, and inhalational plague.
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