Diclofenac amide is a prodrug for Diclofenac sodium ( HY-15037 ). Diclofenac amide is an orally active inhibitor for COX-1/2 , that inhibits the production of prostaglandins (PG) and thromboxanes (TX). Diclofenac amide exhibits anti-inflammatory efficacy in Carrageenan ( HY-125474 )-induced rat paw edema model without causing gastric ulcer (300 μmol/kg).
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