Totrombopag (SB-559448) choline is an orally effective thrombopoietin receptor ( TpoR ) agonist. By activating TpoR , Totrombopag choline initiates an intracellular signaling cascade mediated by JAK2 kinase and the transcription factor Stat5 , a signaling process that is the primary mechanism regulating megakaryocyte growth and differentiation into platelets. Totrombopag choline can be used to study platelet production and megakaryocyte biology.
Products | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Others | Products > Signaling Pathways > Thrombopoietin Receptor
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