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| 2-PYRAZINECARBONYL CHLORIDE Basic information |
| Product Name: | 2-PYRAZINECARBONYL CHLORIDE | | Synonyms: | PYRAZINE-2-CARBONYL CHLORIDE;PYRAZINE-2-CARBOXYLIC ACID CHLORIDE;TIMTEC-BB SBB010290;ASINEX-REAG BAS 07703829;2-PYRAZINECARBONYL CHLORIDE;pyrazinecarbonyl chloride;2-PYRAZINECARBONYL CHLORIDE: TECH.;Pyrazine-2-carbonyl chloride, 90+% | | CAS: | 19847-10-0 | | MF: | C5H3ClN2O | | MW: | 142.54 | | EINECS: | 243-367-4 | | Product Categories: | pharmacetical;Pyridines | | Mol File: | 19847-10-0.mol |
| 2-PYRAZINECARBONYL CHLORIDE Chemical Properties |
| Melting point | 41°C | | Boiling point | 214.5±20.0 °C(Predicted) | | density | 1.393±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -2.50±0.10(Predicted) | | Water Solubility | Reacts with water. | | Sensitive | Moisture Sensitive | | CAS DataBase Reference | 19847-10-0(CAS DataBase Reference) |
| Risk Statements | 34 | | Safety Statements | 26-36/37/39-45 | | RIDADR | 3265 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 2933998090 |
| Provider | Language |
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ALFA
| English |
| 2-PYRAZINECARBONYL CHLORIDE Usage And Synthesis |
| Uses | 2-Pyrazinecarbonyl Chloride is an intermediate used in the synthesis of (S)-N-[1-(3-Hydroxy-3-methylbutanamido)-1-oxo-3-phenylpropan-2yl]pyrazine-2-carboxamide (H805105), which is an impurity of bortezomib (B675700), which is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway. |
| 2-PYRAZINECARBONYL CHLORIDE Preparation Products And Raw materials |
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