Nifurpirinol

Overview

Nifurpirinol (P-7138) is a selective prosubstrate of bacterial nitroreductase (NTR) . NTR catalyzes the reduction of nifurpirinol to generate cytotoxic metabolites that induce apoptosis in target cells. Nifurpirinol selectively ablates NTR-expressing cells such as pancreatic β cells, osteoblasts, dopaminergic neurons, and podocytes in transgenic zebrafish models. Nifurpirinol can be used in regeneration studies and disease modeling such as focal segmental glomerulosclerosis (FSGS).

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Bacterial Infection | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Bacterial

Product Information

• Catalog No.: HY-135470
• CAS No.: 13411-16-0
• Molecular Formula: C12H10N2O4
• Molecular Weight: 246.22
• Purity: 98.70%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 1 mg/mL (4.06 mM); Clear solution
• Availability: In-stock

Source

Original product source