DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC 50 s of 0.13 μM and 47.4 μM, and K i s of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity.
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