SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC 50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC 50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research.
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