NBI-42902

Overview

NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC 50 value of 0.79 nM, a K i value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate ( IP ) accumulation, Ca 2+ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Others | Products > Signaling Pathways > GnRH Receptor | Products > Signaling Pathways > PERK

Product Information

• Catalog No.: HY-13699
• CAS No.: 352290-60-9
• Molecular Formula: C27H24F3N3O3
• Molecular Weight: 495.49
• Purity: 98.65%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (5.05 mM); Clear solution; Need ultrasonic
• Availability: In-stock

Source

Original product source