10'-Desmethoxystreptonigrin is an inhibitor for Ras Farnesyltransferase with an IC 50 of 21 μM. 10'-Desmethoxystreptonigrin is a broad-spectrum antibiotic with antibacterial activity. 10'-Desmethoxystreptonigrin exhibits antitumor activity against P388 leukemia, without significant cytotoxicity (LD 50 is 8.8 mg/kg).
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