LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849. (Pink: KRas G12C ligand ( HY-130149 ); Blue: VHL ligand ( HY-125845B ); Black: linker).
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