Arbutin

Arbutin
  • CAS No.:497-76-7

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
Other grades of this product :

Melting point 195-198 °C
alpha -64 º (c=3)
Boiling point 375.31°C (rough estimate)
density 1.3582 (rough estimate)
refractive index -65.5 ° (C=4, H2O)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 50 mg/mL hot, clear
form neat
pka10.10±0.15(Predicted)
color White
optical activity[α]/D -64.0±2.0°, c = 3 in H2O
Water Solubility 10-15 g/100 mL at 20 ºC
Sensitive Hygroscopic
Merck 14,773
BRN 89673
Stability:Stable. Hygroscopic - store under dry nitrogen.
InChIKeyBJRNKVDFDLYUGJ-RMPHRYRLSA-N
CAS DataBase Reference497-76-7(CAS DataBase Reference)
EPA Substance Registry System.beta.-D-Glucopyranoside, 4-hydroxyphenyl (497-76-7)

β - arbutin, which originated from natural green plants, is a skin whitening active substance with the concepts of "green", "safe" and "efficient". It can quickly penetrate into the skin, effectively inhibit the activity of tyrosinase in the skin, block the formation of melanin, accelerate the decomposition and excretion of melanin through the combination of itself and tyrosinase, so as to reduce the accumulation of skin pigment and remove the spots and freckles. It has no toxic, irritant, sensitizing and other side effects, and it also has the functions of moistening skin, increasing wound, sterilization and synergistic anti-inflammatory. It is one of the most safe and effective whitening materials popular abroad, and also the most competitive skin whitening and freckle removing active agent in the 21st century.

Precautions for use:            
1. Arbutin is easy to decompose in acid environment, and the pH value of the system should be controlled above 6.0; 
2. The Arbutin should be dissolved in a small amount of water at 45 ℃, and added at 45 ℃ after the cream is emulsified completely;
3. An appropriate amount of antioxidant such as sodium bisulfite should be added to the formulation system; 
4. The formulation can be effectively compatible with zwitterionic surfactant and anionic surfactant;            
5. The natural vegetable oil containing oleic acid and linoleic acid can promote the synergistic effect of Arbutin; 
6. Azone and octadecyl dimethylamine can promote the absorption of Arbutin;    
7.Recommended dosage: 2-7%

Packaging: 1kg aluminum foil bag; 25kg / cardboard barrel;
Storage and transportation: dark, sealed, stored in a dry place



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