HT1171 is a potent and selective inhibitor of mycobacterium tuberculosis proteasome . HT1171 shows strong anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv with an MIC 90 of 2 μg/mL and an MIC of 4 μg/mL. When HT1171 concentration is 100 μM, the inhibition rate of human normal hepatocytes L02 is 53.8%. HT1171 can be used in the research of antitubercular agent.
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