Doxepin -d 3 is the deuterium labeled Doxepin ( HY-B0725A ). Doxepin s an orally active tricyclic antidepressant agent. Doxepin is a potent and selective histamine receptor H1 antagonist. Doxepin is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2. Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis, chronic urticarial, can improve cognitive processes, protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress.
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