NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC 50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC 50 >100 μM).
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