HEPES

Melting point	234-238 °C
density	1.07 g/mL at 20 °C
refractive index	n20/D1.339
storage temp.	2-8°C
solubility	H2O: 1 M at 20 °C, clear, colorless
form	powder
color	White
PH	5.0-6.5 (1Maqueous solution)
PH Range	7.0 - 7.6
pka	7.5(at 25℃)
Water Solubility	Soluble
λmax	λ: 260 nm Amax: 0.06 λ: 280 nm Amax: 0.04
Merck	14,4654
BRN	883043
Stability:	Stable. Combustible. Incompatible with strong oxidizing agents. Protect from moisture.
InChIKey	JKMHFZQWWAIEOD-UHFFFAOYSA-N
CAS DataBase Reference	7365-45-9(CAS DataBase Reference)
EPA Substance Registry System	1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)- (7365-45-9)

Hydroxyethylpiperazine ethane sulfonic Acid is a kind of amphoteric buffer, which is widely used in cell culture medium, protein, IVD kit and other fields. It has the function of exfoliation, auxiliary penetration and stabilizing product quality in cosmetics.

Hydroxyethylpiperazine ethane sulfonic acid can be used as a peeling agent. It can be applied to skin in any form, including emulsion, gelatin or cream. As a peeling agent, a mixture of glycolic acid, lactic acid and hydroxyethyl piperazine ethane sulfonic acid can be used. Hydroxyethylpiperazine ethane sulfonic acid is also an effective component to promote skin surface metabolism. In addition, Hydroxyethylpiperazine ethane sulfonic acid is used as permeation enhancer to promote the transdermal absorption of various functional components in cosmetics.

Hydroxyethylpiperazine ethane sulfonic acid is used to balance the properties of its acidic counterpart. Because it can keep the pH constant in the chemical reaction process, it is often paired with glycolic acid and other components, which helps to prolong and maintain the quality of skin care products.