MS67 is a potent and selective WD40 repeat domain protein 5 ( WDR5 ) degrader with a K d of 63 nM. MS67 is inactive against other protein methyltransferases, kinases, GPCRs, ion channels, and transporters. MS67 shows potent acticancer effects. (Pink: WDR5 ligand ( HY-184594 ); Blue: VHL ligand ( HY-112078 ); Black: linker).
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