PROTAC-O4I2

Overview

PROTAC-O4I2 is a PROTAC targets splicing factor 3B1 ( SF3B1 ). PROTAC-O4I2 induces FLAG-SF3B1 degradation with an IC 50 value of 0.244 μM in K562 cells. PROTAC-O4I2 also induces cellular apoptosis in K562 WT cells. (Pink: SF3B1 ligand ( HY-18772 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-W008296 )).

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > SF3B1

Product Information

• Catalog No.: HY-141881
• CAS No.: 2785323-62-6
• Molecular Formula: C29H29ClN6O5S
• Molecular Weight: 609.10
• Purity: 99.56%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (3.41 mM); Clear solution
• Availability: In-stock

Source

Original product source