MK-1220 is a covalently reversible inhibitor of the hepatitis C virus ( HCV ) NS3/4A protease ( NS3/4A protease ) with a K i of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC 50 s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum). MK-1220 can be used for the study of chronic hepatitis C virus infection .
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