AhR agonist 2 (Compound 12a) is a potent agonist of aryl hydrocarbon receptor ( AhR ) with an EC 50 of 0.03 nM. AhR agonist 2 induces rapid nuclear enrichment of AhR, triggers the transcription of downstream genes and promote skin barrier repair. AhR agonist 2 has the potential for the research of psoriasis.
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