PROTAC EGFR degrader 3

Overview

PROTAC EGFR degrader 3 is a selective EGFR mutant PROTAC degrader with activity against EGFR L858R/T790M and EGFR del19 , with DC 50 values of 1.56 nM and 0.49 nM, respectively. PROTAC EGFR degrader 3 induces degradation via formation of a ternary complex with VHL , ubiquitination, and lysosomal processing. PROTAC EGFR degrader 3 inhibits tumor cell proliferation. PROTAC EGFR degrader 3 can be used for the research of non-small cell lung cancer . (Pink: EGFR ligand ( HY-150905 ); Blue: VHL ligand ( HY-112078 ); Black: linker).

Application

Products | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-144605
• CAS No.: 2768472-28-0
• Molecular Formula: C60H77N13O5S
• Molecular Weight: 1092.40
• Purity: 97.39%
• Storage: 4°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (2.29 mM); Clear solution
• Availability: In-stock

Source

Original product source