Mpro/PLpro-IN-1 (Compound 29) is a potent inhibitor of M pro / PL pro . Mpro/PLpro-IN-1 is a dual acting SARS-CoV-2 proteases inhibitor featuring micromolar inhibitory potency versus M pro ( IC 50 = 1.72 μM) and submicromolar potency versus PL pro ( IC 50 = 0.67 μM).
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