SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease ( 3CLpro ) with an IC 50 and EC 50 of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease ( 3CLpro ), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals.
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