Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir ( HY-17438 ), is an orally available, long-acting antiviral . Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus ( CMV ), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo.
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