GS-8873 is an orally active inhibitor for the production of hepatitis B virus ( HBV ) surface antigen ( HBsAg ) with an EC 50 of 4 nM. GS-8873 exhibits good pharmacokinetic characters in rats and metabolic stability in human hepatocytes. GS-8873 causes neurofunctional deficits in rats and cynomolgus monkeys.
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