IKKβ-IN-1 is a potent and orally active IkappaB ( IKK-β ) inhibitor with IC 50 of 0.20 μM. IKKβ-IN-1 can reduce PGE 2 and TNF-α production in mouse macrophage cells. IKKβ-IN-1 has the ability to protect mice against septic shock induced mortality.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > NF-κB | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > IKK
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