Tebideutorexant is an OX1R -selective inhibitor with oral bioavailability and blood-brain barrier permeability, with human OX1R pK i 8.17 and rat OX1R pK i 8.13.Tebideutorexant selectively modulates OX1R , with no significant functional effect on OX2R . Tebideutorexant can be used for the research of panic and anxiety disorders.
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