L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus ( EBV ) agent with an EC 50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC 50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis.
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