KTX-951

Overview

KTX-951 is an orally active PROTAC degrader of IRAK4 and IMiD (Ikaros/Aiolos) substrates ( K d = 3.5 nM). KTX-951 induces IRAK4 degradation, and the degradation efficiency is independent of IRAK4 binding affinity. The DC 50 values of KTX-951 for IRAK4 , Ikaros and Aiolos are 18 nM, 14 nM and 13 nM, respectively. The IC 50 of KTX-951 against OCl-Ly10 CTG is 35 nM. KTX-951 exhibits antitumor activity. (Pink: IRAK4 ligand ( HY-48932 ); Blue: Cereblon ligand ( HY-10984 ); Black: linker ( HY-W382009 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > IRAK

Product Information

• Catalog No.: HY-148290
• CAS No.: 2573298-36-7
• Molecular Formula: C46H52F2N8O6
• Molecular Weight: 850.95
• Purity: 99.60%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source