UCK2 Inhibitor-3

Overview

UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 ( UCK2 , a pyrimidine salvage enzyme) with an IC 50 value of 16.6 μM. UCK2 can replace dihydroorotate dehydrogenase ( DHODH ), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC 50 s of 56 μM and 16 μM.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-148396
• CAS No.: 2376687-49-7
• Molecular Formula: C19H13BrFN5O2S
• Molecular Weight: 474.31
• Purity: 98.65%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (10.54 mM); Clear solution
• Availability: In-stock

Source

Original product source