Picoberin is a low picomolar inhibitor of Hedgehog -induced osteoblast differentiation. Picoberin is a potent aryl hydrocarbon receptor ( AhR ) agonist. Picoberin inhibits Wnt3A-induced osteoblast differentiation of C3H10T1/2 cells. Picoberin can upregulate genes encoding phase I and II metabolic enzymes .
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