Viral polymerase-IN-1 hydrochloride, a Gemcitabine ( HY-17026 ) derivative, potently inhibits influenza A and B viruses infection with IC 90 values of 11.4-15.9 μM. Viral polymerase-IN-1 hydrochloride is active against SARS-CoV-2 infection . Viral polymerase-IN-1 hydrochloride suppresses influenza virus infection by affecting viral RNA replication/transcription in cells.
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