SZM-1209 is an orally active, potent and specific RIPK1 inhibitor, with a K d of 85 nM. SZM-1209 exhibits high anti-necroptotic activity ( EC 50 =22.4 ± 8.1 nM). SZM-1209 shows anti-SIRS (systemic inflammatory response syndrome), and anti-ALI (acute lung injury) effects.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > Mixed Lineage Kinase | Products > Signaling Pathways > Necroptosis
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