HAA-09 is an orally active and potent anti-influenza agent, targeting the influenza PB2_cap binding domain. HAA-09 displays potent anti- influenza A virus activity, with an EC 50 of 0.03 μM. HAA-09 shows polymerase inhibition, with an IC 50 of 0.06±0.004 μM. HAA-09 blocks virus replication without causing obvious cytotoxicity.
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