COX-2-IN-31 (compound 7b) is an orally active and dual inhibitor of COX-2 ( IC 50 =60 nM) and 5-LOX ( IC 50 =1.9 μM). COX-2-IN-31 also inhibits transmembrane hCA IX( K i =48.9 nM) and hCA XII( K i =5.8 nM) activity. COX-2-IN-31 exhibits anti-inflammatory and analgesic activity.
Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > COX
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