JNJ-8003

Overview

JNJ-8003 is a potent and orally active non-nucleoside RSV polymerase inhibitor with an IC 50 of 0.29 nM. JNJ-8003 targets the L protein polymerase complex of RSV ( IC 50 = 0.67 nM), and blocks the transcription and replication of the viral genome by inhibiting the activity of RNA-dependent RNA polymerase ( RdRp ). JNJ-8003 displays subnanomolar activity in vitro as well as prominent efficacy in mice and a neonatal lamb models. JNJ-8003 can be used for the study of respiratory syncytial virus ( RSV ).

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Anti-infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Infection | Products > Signaling Pathways > RSV | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-149648
• CAS No.: 3118087-68-3
• Molecular Formula: C28H25F5N4O4
• Molecular Weight: 576.51
• Purity: 99.84%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source