Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC 50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC 50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
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