ARN1468

Overview

ARN1468 (compound 5) is an orally active and potent SerpinA3n inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Infection | Products > Signaling Pathways > Prion Protein

Product Information

• Catalog No.: HY-150514
• CAS No.: 1381459-14-8
• Molecular Formula: C16H17F3N4O2
• Molecular Weight: 354.33
• Purity: 98.96%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source