XO/COX/LOX-IN-1 is a XO / COX / LOX inhibitor with an IC 50 of 3.2 μM against rat XO , 10.83 μM against 5-LOX , 12.67 μM against COX-1 , and 8.31 μM against COX-2 . XO/COX/LOX-IN-1 binds to the active sites of XO , 5-LOX , COX-1 and COX-2 , thereby blocking enzyme activities associated with uric acid, leukotriene, prostaglandin synthesis and inflammatory pathways. XO/COX/LOX-IN-1 can be used in the research of hyperuricemia and inflammation.
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