IBG1 is a molecular glue degrader targeting BRD2 and BRD4 ( DC 50 : 0.15 nM). IBG1 has no significant degradation effect on its paralogue BRD3 . IBG1 can inhibit the growth of cancer cells and can be used in tumor research. (Pink: BRD2/BRD4 Ligand ( HY-111139 ); Black: Linker; Blue: DCAF15 ligand-1 ( HY-W037495 )).
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