PROTAC MEK1 Degrader-1

Overview

PROTAC MEK1 Degrader-1 is a PROTAC targeting MEK1 with a pIC 50 value of 7.0. PROTAC MEK1 Degrader-1 consists of a MEK1 inhibitor and a von Hippel-Lindau ligand. PROTAC MEK1 Degrader-1 can inhibit ERK1/2 phosphorylation. PROTAC MEK1 Degrader-1 shows an antiproliferative activity against A375 cells. (Pink: MEK1 ligand ( HY-175585 ); Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-33366 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > MEK | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-153864
• CAS No.: 2671004-41-2
• Molecular Formula: C53H66FIN8O11S2
• Molecular Weight: 1201.17
• Purity: 98.03%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.08 mM); Clear solution
• Availability: In-stock

Source

Original product source