Roflumilast-d 4 is the deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC 50 s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1 , PDE2 , PDE3 or PDE5 isoenzymes from various cells.
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